Intestinal epithelial cells in inflammatory bowel diseases
نویسندگان
چکیده
منابع مشابه
Special Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells Brief Review Inflammatory bowel diseases and intestinal epithelial stem cells
Recent studies on human inflammatory bowel diseases (IBD) have brought our attention to continued epithelial injury and impaired epithelial regeneration as their key pathophysiological features. In order to develop a novel approach for the treatment of IBD, it is important to understand the ordered process of epithelial repair and the pivotal roles for the epithelial stem cells in this process....
متن کاملSpecial Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells
The development of colorectal cancer caused by chronic inflammatory bowel disease (IBD) is the representative example of inflammation-associated carcinogenesis. The mechanism underlying the development of colorectal cancers through chronic inflammation, however, is not known. Activation-induced cytidine deaminase (AID) was originally identified as an inducer of somatic hypermutation in the immu...
متن کاملSpecial Issue: Inflammatory Bowel Diseases and Intestinal Epithelial Stem Cells
Adult stem cells have the capacity to self-renew and to regenerate tissues long-term, in both homeostasis and wound repair. Genetic lineage tracing studies have identified two principal stem cell populations in the intestine. One population consists of actively cycling Lgr5+ cells residing at the crypt base. The other population consists of quiescent Bmi1+ cells that largely reside at approxima...
متن کاملEpithelial regeneration in inflammatory bowel diseases
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn’s disease, are characterized not only by the sub-mucosal accumulation of inflammatory cells, but also by the severe damage of the epithelial layer. Recent clinical studies have featured “mucosal healing” as the most significant prognostic factor for long-term remission in IBD patients, suggesting that accomplishment of ep...
متن کاملCross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease
Inflammatory bowel disease (IBD) involves functional impairment of intestinal epithelial cells (IECs), concomitant with the infiltration of the lamina propria by inflammatory cells. We explored the reciprocal paracrine and direct interaction between human IECs and macrophages (MΦ) in a co-culture system that mimics some aspects of IBD. We investigated the expression of intercellular junctional ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2010
ISSN: 1007-9327
DOI: 10.3748/wjg.v16.i34.4264